The specific external exposures cover a large range of exposures that the individual could be exposed to, such as lifestyle factors, medical interventions, environmental pollutants etc. The general external exposures are the wider exposures that an individual can be exposed to such as mental stress, climate, living environment etc. 2 a three-domain division of the exposome: internal, general external and specific external. not just a cross-sectional evaluation of exposures but also their change over time. 1 This concept refers to the totality of environmental and lifestyle exposures of an individual over the lifespan, i.e. The exposome concept was first described by Wild in 2005. Exposome, Shiny, R, graphical user interface, toolbox, epidemiology, ExWAS, biological insights, omics-exposures association Introduction
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